Vimentin filaments in a cell, visualized by fluorescence microscopy

Decodinglife’s beginnings.探索生命起始的秩序

Gene regulation. Development. Reproduction.基因调控 · 发育 · 生殖

About the image关于这幅影像

Image by Andy Moore · HHMI, Janelia Research Campus. Vimentin Dreamcatcher. Fluorescence microscopy. Used under CC BY-NC 4.0; displayed at responsive sizes. A reference image, not a YuanLab research result.影像：Andy Moore · HHMI Janelia Research Campus。Vimentin Dreamcatcher，荧光显微成像。采用 CC BY-NC 4.0 许可，按屏幕尺寸缩放展示。此为生物学参考影像，并非 YuanLab 的实验成果。

HHMI Beautiful Biology ↗ · CC BY-NC 4.0 ↗

How does a genome give rise to life?从基因调控，理解生命的开始。

We study embryonic gene regulation, meiotic chromatin regulation and transcript diversity through experimental and computational approaches.结合实验与计算方法，研究胚胎基因调控、减数分裂中的染色质调控与转录本多样性。

Meet YuanLab了解袁慎立课题组

Early development早期发育

Zygotic genome activation and chromatin reprogramming in early embryos.早期胚胎中的合子基因组激活与染色质重编程。

Chromatin regulation染色质调控

Investigating histone modifications, chromatin accessibility and meiotic regulation.研究组蛋白修饰、染色质可及性与减数分裂调控。

Transcriptome diversity转录组多样性

Long-read and single-cell analyses of transcript isoforms and allelic expression.转录本异构体与等位基因表达的长读长及单细胞分析。

Fluorescent microtubule networks in adjacent cells

A closer look. A deeper understanding.看见微观，理解生命。

We investigate gene regulation in early development and reproduction, combining epigenomics with transcriptome analysis.结合表观基因组学与转录组分析，研究早期发育与生殖中的基因调控。

Image credits影像来源

Cellular Spiderwebs · Andy Moore, HHMI, Janelia Research Campus · Beautiful Biology ↗ · CC BY-NC 4.0 ↗

Reference microscopy image; responsive crop and dark overlay for legibility.生物学参考影像；响应式局部展示，并叠加暗色以确保文字清晰。

Research in focus研究聚焦

All publications全部论文

Complete Figure 1: mouse sample and sequencing workflow, transcript classes, sample correlations, PCA, transcript lengths, exon counts and isoform counts. — Figure & credits图版与来源
Figure 1图 1Wu et al. · Journal of Ovarian Research (2026)Wu 等 · Journal of Ovarian Research（2026） · Source出处 · CC BY-NC-ND 4.0

2026 · Journal of Ovarian Research

Reading the full story of a transcriptome.读懂转录组的完整故事。

Long-read RNA sequencing profiles full-length transcripts in granulosa cells and oocytes from young and aged mice. The study identifies age-associated isoform changes, alternative polyadenylation and differences in predicted coding potential.通过长读长 RNA 测序解析年轻与衰老小鼠颗粒细胞和卵母细胞的全长转录本，识别与年龄相关的异构体变化、可变多聚腺苷酸化及预测编码潜能差异。

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