Blood cells and vessels on the yolk of a two-day-old zebrafish embryo

Decodinglife’s beginnings.探索生命起始的秩序

Gene regulation. Development. Reproduction.基因调控 · 发育 · 生殖

How does a genome give rise to life?从基因调控，理解生命的开始。

We study embryonic gene regulation, meiotic chromatin regulation and transcript diversity through experimental and computational approaches.结合实验与计算方法，研究胚胎基因调控、减数分裂中的染色质调控与转录本多样性。

Meet YuanLab了解袁慎立课题组

Early development早期发育

Zygotic genome activation and chromatin reprogramming in early embryos.早期胚胎中的合子基因组激活与染色质重编程。

Chromatin regulation染色质调控

Investigating histone modifications, chromatin accessibility and meiotic regulation.研究组蛋白修饰、染色质可及性与减数分裂调控。

Transcriptome diversity转录组多样性

Long-read and single-cell analyses of transcript isoforms and allelic expression.转录本异构体与等位基因表达的长读长及单细胞分析。

Neurons and cell nuclei in the developing cerebellum of a mouse embryo

A closer look. A deeper understanding.看见微观，理解生命。

We investigate gene regulation in early development and reproduction, combining epigenomics with transcriptome analysis.结合表观基因组学与转录组分析，研究早期发育与生殖中的基因调控。

Research in focus研究聚焦

All publications全部论文

Complete Figure 1: H3K18cr genomic profiles, peak statistics and immunostaining across mouse gametes and early embryos, with all original labels and microscopy scale bars.

2026 · Advanced Science

A new layer of life's first signals.解读生命起始的表观遗传信号。

The study maps H3K18 crotonylation in mouse gametes and preimplantation embryos. It examines how remodeling of this histone mark interacts with zygotic genome activation and early development.研究绘制小鼠配子与植入前胚胎的 H3K18 巴豆酰化图谱，探索这一组蛋白修饰的重塑与合子基因组激活及早期发育之间的联系。

Read the paper阅读论文

Complete Figure 1: human parthenogenetic and androgenetic embryo design, gene-level RNA-seq heatmap and newly transcribed gene comparisons.

2023 · Cell Discovery

How the embryonic genome awakens.胚胎基因组，如何苏醒？

Using human parthenogenetic and androgenetic embryos, the study investigates parental contributions to zygotic genome activation. It identifies paternal expression of ZNF675 and LSM1 as part of the regulatory process.利用人类孤雌与孤雄胚胎研究双亲基因组对合子基因组激活的贡献，并探讨父源表达的 ZNF675 和 LSM1 在这一过程中的作用。

Read the paper阅读论文

Complete Figure 1: human embryo study design, chromatin accessibility, H3K27me3 and DNA methylation patterns, allele-related expression and imprinted-gene genome tracks.

2024 · National Science Review

Two parental genomes. A new beginning.双亲基因组，共同开启新生命。

Parental epigenomic maps of human early embryos reveal allele-specific chromatin reprogramming. Comparisons with mouse embryos identify differences in parental epigenetic states and genomic imprinting.通过人类早期胚胎的亲本表观基因组图谱，刻画等位基因特异的染色质重编程，并比较人和小鼠在亲本表观遗传状态及基因组印记上的差异。

Read the paper阅读论文

Complete Figure 4: DMC1, ZCWPW1 and ATAC-seq genome tracks and heatmaps comparing wild-type, Zcwpw1, Prdm9 and Spo11 mutant mouse testes.

2022 · Genome Biology

Reading chromatin at meiotic hotspots.在减数分裂热点，读取染色质。

The study investigates how the histone reader ZCWPW1 connects histone modifications with chromatin accessibility at meiotic recombination hotspots. The results link this regulation to homologous recombination during DNA double-strand break repair.研究探讨组蛋白修饰识别蛋白 ZCWPW1 如何联结减数分裂重组热点处的组蛋白修饰与染色质可及性，以及这一调控与 DNA 双链断裂同源重组修复的关系。

Read the paper阅读论文

Complete Figure 1: mouse sample and sequencing workflow, transcript classes, sample correlations, PCA, transcript lengths, exon counts and isoform counts.

2026 · Journal of Ovarian Research

Reading the full story of a transcriptome.读懂转录组的完整故事。

Long-read RNA sequencing profiles full-length transcripts in granulosa cells and oocytes from young and aged mice. The study identifies age-associated isoform changes, alternative polyadenylation and differences in predicted coding potential.通过长读长 RNA 测序解析年轻与衰老小鼠颗粒细胞和卵母细胞的全长转录本，识别与年龄相关的异构体变化、可变多聚腺苷酸化及预测编码潜能差异。

Read the paper阅读论文